Clinical Trials Activity initiative

The Clinical Trials Activity initiative will provide $750 million over 10 years from 2024–25. It will help Australian researchers and patients test new treatments through national and international clinical trials. It will also support research on rare cancers, rare diseases and unmet needs.

About the Clinical Trials Activity initiative

The Clinical Trials Activity initiative will provide $750 million over 10 years between 2024–25 and 2033–34 to increase clinical trial activity in Australia.

The focus of this initiative is on:

  • clinical trials addressing rare cancers, rare diseases, and unmet needs
  • bringing investigator-led international clinical trials to Australia
  • effective health interventions (i.e. research projects focused on implementation science and comparative effectiveness research).

The initiative also funds research projects focused on any disease or condition that meets the objective specified in each grant opportunity.

Why it is important

This initiative is important because it supports clinical trials that test the effectiveness of therapies and treatments and create the evidence needed to improve clinical practice.


The objective of this initiative is to increase clinical trial activity in Australia to:

  • improve the evidence base supporting clinical care
  • help patients access trials relevant to their health circumstances
  • enable researchers to bring international trials to Australian patients.

Meeting our objectives

We will monitor the initiative in accordance with the principles and approach detailed in the MRFF Monitoring, evaluation and learning strategy.

Who we work with

The Medical Research Future Fund (MRFF) funds the initiative.

Our Health and Medical Research Office oversees this and other MRFF initiatives.

The National Health and Medical Research Council (NHMRC) administers this initiative.

Apply for funding

View the MRFF grants calendar to see which grants are open, when applications close and when we expect to award funding.

Register with GrantConnect to receive notifications about future funding opportunities under this initiative.

Grants awarded

See a list of all MRFF grant recipients.

Monitoring, evaluation and learning

In 2021, we commissioned the Institute for Evidence-Based Healthcare (IEBH), Bond University, to evaluate this initiative. The evaluation looked at:

  • investments in clinical trials made through the MRFF
  • approaches for clinical trials overseas and in Australia
  • ways to improve funding and granting arrangements for clinical trials through the initiative and the MRFF more broadly.

It also reviewed this initiative’s:

Read the outcomes of the Evaluation of the MRFF Clinical Trials Activity.

Learn about MRFF monitoring, evaluation and learning.

More information is available from


For more information, contact us.

Medical Research Future Fund (MRFF) contact

Contact for more information about the Medical Research Future Fund (MRFF), or to provide feedback on the MRFF website.
General enquiries:
Evaluations enquiries:
MRFF website or newsletter feedback:

National Health and Medical Research Council (NHMRC)

The National Health and Medical Research Council (NHMRC) funds high quality health and medical research to build research capability, support researchers, encourage the translation of research into better health outcomes and promote the highest ethical standards for health and medical research.
Date last updated:

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