ATAGI statement on recommendations on a winter booster dose of COVID-19 vaccine

The Australian Technical Advisory Group on Immunisation (ATAGI) has made recommendations on a winter booster dose of COVID-19 vaccine

Date published:
Audience:
General public

Summary

ATAGI recommends an additional booster dose of COVID-19 vaccine to increase vaccine protection before winter for selected population groups (see Table 1) who are at greatest risk of severe illness from COVID-19 and who have received their primary vaccination and first booster dose. These groups are:

  • Adults aged 65 years and older
  • Residents of aged care or disability care facilities
  • People aged 16 years and older with severe immunocompromise (as defined in the  ATAGI statement on the use of a 3rd primary dose of COVID-19 vaccine in individuals who are severely immunocompromised)
  • Aboriginal and Torres Strait Islander people aged 50 years and older.

The additional winter booster dose can be given from 4 months or longer after the person has received their first booster dose, or from 3 months after a confirmed SARS-CoV-2 infection, if infection occurred since the person’s first COVID-19 booster dose.

The additional winter booster dose is now available to coincide with the 2022 influenza vaccination program.

Influenza vaccine can be co-administered with the additional booster dose of COVID-19 vaccine. However, if a person is not yet eligible for their additional booster dose, influenza vaccine could be given ahead of the additional booster dose.

Comirnaty (Pfizer) or Spikevax (Moderna) are the preferred vaccines for COVID-19 booster doses including the additional winter booster dose. Vaxzevria (AstraZeneca) can be used when an mRNA vaccine is contraindicated or a person declines vaccination with an mRNA vaccine. Nuvaxovid (Novavax) can be used if no other COVID-19 vaccine is considered suitable for that person.

For other groups not listed above, there is insufficient evidence of the benefits of an additional booster dose to make recommendations at this time. This includes people younger than 65 years with medical conditions that may increase their risk of COVID-19, individuals with disability and National Disability Insurance Scheme (NDIS) recipients who are not in residential disability care, Aboriginal and Torres Strait Islander people aged 16 to 49, workers at health care or residential care facilities, or younger healthy adults. ATAGI will continue to monitor emerging evidence and may recommend an additional dose for these groups in the future.

Prevention of severe illness from COVID-19 remains the primary goal of the ongoing COVID-19 vaccination program. These recommendations for an additional booster dose focus on protecting the most vulnerable groups against severe disease and reducing the potential burden on the healthcare system over the coming months.

The secondary aims of the COVID-19 vaccination program are preventing infection and preventing transmission of the virus. There is limited evidence at this stage for additional booster doses to prevent transmission. Emerging evidence in relation to prevention of transmission by vaccination will continue to be monitored and additional booster doses may be recommended in additional groups in the future.

All people aged 16 years and older are recommended to receive a first booster dose of COVID-19 vaccine after completing their primary course. For most people, this will be a third dose. The booster dose is important to maintain protection against COVID-19.

For any person aged 16 and older who has not received their first booster yet, ATAGI recommends they receive it as soon as possible.

Protection against infection wanes after the first booster dose. However, protection against severe disease (rather than all infection) is relatively well maintained, especially in young healthy populations.

Target group

Recommendation for additional booster dose

Comments/information gaps/next steps

People aged ≥65 years

Recommended

Recommended from 4 months after the previous booster dose, or from 3 months after previous SARS-CoV-2 infection if this occurred since the previous booster dose.

Residents of aged care or disability care facilities

Recommended

Includes people with disability in group residential care facilities.

Includes people in residential aged care or disability care who are aged <65 years.

Recommended from 4 months after the previous booster dose, or from 3 months after previous SARS-CoV-2 infection if this occurred since the previous booster dose.

People who are severely immunocompromised aged 16 years

Recommended for people with severe immunocompromise, as defined in the ATAGI statement on use of a 3rd primary dose of COVID-19 vaccine in individuals who are severely immunocompromised

This will be a 5th dose as this group is recommended to receive 3 primary doses.

Recommended from 4 months after the previous booster dose, or from 3 months after previous SARS-CoV-2 infection if this occurred since the previous booster dose.

Aboriginal and Torres Strait Islander people aged ≥50 years

Recommended

Recommended from 4 months after the previous booster dose, or from 3 months after previous SARS-CoV-2 infection if this occurred since the previous booster dose.

People aged <65 years with medical conditions that may increase their risk of COVID-19[1]

Not currently recommended.

Remains under active consideration

Complete primary schedule. Promote first booster dose, if not already given.

ATAGI will continue to evaluate emerging evidence over the coming weeks.

Health care, aged care and disability care workers

Complete primary schedule. Promote first booster dose, if not already given.

ATAGI will continue to evaluate emerging evidence over the coming weeks. Maximise up to date vaccination of patients under care.

All others aged 16–64 years

Complete primary schedule. Promote first booster dose, if not already given.

ATAGI will continue to evaluate emerging evidence over the coming weeks.

All others aged 5–15 years

Complete primary schedule. ATAGI will evaluate emerging evidence over the coming weeks regarding the first booster dose.

  • 1 except for people who are severely immunocompromised as defined in the ATAGI statement on use of a 3rd primary dose of COVID-19 vaccine

Introduction

The virus that causes COVID-19 (SARS-CoV-2) is now endemic in Australia. The Omicron SARS-CoV-2 variant of concern has become the dominant strain globally.

The first booster doses of COVID-19 vaccine were rolled out in November 2021. The interval between the last primary dose and the booster dose was reduced from 6 months to 3 months by 31 January 2022 as evidence emerged and to maximise the number of people who could be vaccinated with booster doses as the Omicron wave evolved.

While the original BA.1 Omicron wave is now past its peak, the BA.2 subvariant is rapidly replacing BA.1. This subvariant is more transmissible and likely to cause a resurgence of cases.1 The severity of disease and protection after vaccination appear to be similar between BA.1 and BA.2.2,3

As of 13 March 2022, cumulative uptake of the third dose (the first booster dose for most people, except for severely immunocompromised people) is 65.6% of those eligible.4 ATAGI emphasises the importance of a first booster dose of COVID-19 vaccine for all people aged 16 years and older.

There have been approximately 3 million cases of COVID-19 since 5 December 2021, and the vast majority of cases have been mild in severity.5,6 Some degree of immunity is to be expected after infection, although the level and duration of this in the context of Omicron infection and protection against future variants is unknown.

Prevention of severe illness from COVID-19 remains the primary goal of the ongoing COVID-19 vaccination program. There is a need to consider how best to use COVID-19 vaccines to protect those most at risk of severe disease, hospitalisation and death. Vaccination program priorities may continue to change in the future based on the emergence of new variants and/or new vaccines.

ATAGI has reviewed the available evidence on the duration of protection given by COVID-19 vaccines (including booster doses) and the epidemiology of SARS-CoV-2, to assess the benefit from and optimal timing of further booster doses in people who are currently up to date with COVID-19 vaccination. ATAGI acknowledges that uncertainties remain regarding the potential for new variants; the benefits, safety and optimal timing of additional doses in different groups; and the potential development of new COVID-19 vaccines.

Recommendations

Based on currently available evidence, ATAGI recommends an additional booster dose of COVID-19 vaccine to increase vaccine protection for winter. This winter booster dose is available for specified populations who are at increased risk of severe disease. These groups are:

  • Adults aged 65 years and older
  • Residents of aged care or disability care facilities (including those under 65 years)
  • People aged 16 years and older with severe immunocompromise as defined in the ATAGI statement on use of a 3rd primary dose of COVID-19 vaccine in individuals who are severely immunocompromised)
  • Aboriginal and Torres Strait Islander adults aged 50 years and older.

There is currently insufficient evidence to recommend additional booster doses for other population groups, including:

  • People with medical risk factors
  • Individuals with disability and National Disability Insurance Scheme (NDIS) recipients who are not in residential disability care
  • Aged care, disability care and healthcare workers
  • Healthy individuals aged 16 to 64 years.
  • Aboriginal and Torres Strait Islander people aged under 50 years.

ATAGI will actively monitor emerging evidence about booster vaccination in these groups and provide updated advice if needed.

Timing of the additional COVID-19 vaccine booster dose for high-risk populations

The additional booster dose can be given from 4 months or longer since the first COVID-19 booster dose. In people who have had a confirmed SARS-CoV-2 infection (by PCR or rapid antigen test) after receiving their first booster dose, the additional dose should be given from 3 months after the confirmed infection, as infection has been shown to boost immunity. ATAGI recommends that the additional booster dose can be received from April 2022, coinciding with the rollout of the 2022 influenza vaccination program.

In special circumstances, individuals may be vaccinated at a shorter interval from their last dose or infection. Examples include vaccination outreach programs to aged care or disability care facilities, remote communities, or delivering vaccination services in the context of natural disasters, where some flexibility of the minimum interval may facilitate vaccination of a larger proportion of individuals.

The additional booster dose should not be administered less than 3 months from the previous booster dose or SARS-CoV-2 infection.

Choice of vaccine

Choice of vaccine for the additional winter booster dose aligns with current recommendations for COVID-19 vaccine boosters. For more information see ATAGI Clinical Guidance on the use of COVID-19 vaccines in Australia.

Other population groups

ATAGI does not currently recommend an additional booster dose for healthy people who are not in one of the above groups.

ATAGI also does not consider there to be sufficient evidence of benefits to recommend additional boosters in occupational groups, such as workers in aged care, residential care or health care. This is based on evidence suggesting that protection from booster doses against transmission of the Omicron variant may be limited and short-lived. Evidence also suggests that use of appropriate personal protective equipment in the workplace means that exposure of health care workers occurs more frequently in the community than in the workplace. ATAGI considers there to be more evidence to support direct protection from an additional booster dose to those at highest risk of severe disease in these settings – residents and patients. Maintaining infection control procedures by workers at aged care and healthcare facilities remains  important to minimise transmission of SARS-CoV-2 between staff, residents and patients.

ATAGI will continue to monitor evidence on the epidemiology of SARS-CoV-2, including the BA.2 subvariant, the potential emergence of new variants, waning of immunity against severe disease after the first booster dose, and protection against Omicron transmission, and will update its advice if required.

Rationale

Key considerations in the review of evidence for a second booster dose included the effectiveness of 3 doses in maintaining protection against severe disease or infection, and whether this changed over time in different population groups, as well as efficacy against onward transmission compared with direct protection against severe disease.

Waning of protection after the first booster dose

Evolving evidence based on early vaccine effectiveness data and analysis of antibody levels after the first booster dose suggest there is gradual waning of immunity against the Omicron variant.7-10 This is most prominent for vaccine effectiveness against symptomatic infection, which declines from 60–75% at 2–4 weeks after a booster dose of either the Pfizer or Moderna vaccine to 25–40% from 15 or more weeks after the booster.3

Vaccine effectiveness against COVID-19 hospitalisation after the first booster dose is high at 88–95% after an mRNA booster,3,7,8,10 and appears to wane more slowly than vaccine effectiveness against symptomatic infection (vaccine effectiveness against hospitalisation was 75% by 10–14 weeks for Pfizer vaccine3 and 78% ≥4 months after mRNA vaccine8). Data from Qatar show that effectiveness against severe disease remained at >90% after 7 weeks or more after the first booster, although this was in a relatively younger population and may not be directly comparable.7 Further data on waning vaccine effectiveness against COVID-19 mortality are expected soon, but initial estimates from the United Kingdom are high at >95% immediately after the first booster dose.3

Benefits of an additional booster dose

Benefits from a second booster dose are supported by limited pre-print data from Israel, which suggest that in higher-risk people (aged ≥60 years), an additional booster dose of Pfizer vaccine at 4 months after a first booster resulted in a 2-fold lower rate of confirmed infection and 4.3-fold lower rate of severe illness.11

Another study in younger people aged ≥18 years showed the additional protection from an additional booster dose to be modest and uncertain. Those who received an additional booster dose were 11–30% less likely to be infected and 31–43% less likely to have symptomatic disease than those who had received only one booster. However, estimates were imprecise due to small numbers of infected people.12

Population groups at risk of severe disease

Older age is the strongest risk factor for severe COVID-19 outcomes and forms the basis for providing an additional booster dose to older adults in the coming months.13 Around 160,000 people aged ≥65 years will be 4 months from their first booster dose as of 1 April 2022.

The age cut-off of 65 years aligns with eligibility for receiving influenza vaccine under the National Immunisation Program, which may facilitate implementation and uptake of the additional booster dose. A 4-month interval also aligns with evidence of waning after the first booster dose, and will allow a large proportion of the eligible population to receive the additional dose before winter. Reducing the burden of COVID-19 in high-risk populations during winter may reduce the strain on the healthcare system.

Some people with disability are at increased risk of severe COVID-19, but this risk can vary widely. The risk is higher for people who live in group residential settings,14 who may also be more likely to have severe disability, which is itself a risk factor.15

Severely immunocompromised people have a suboptimal response to COVID-19 vaccines compared with immunocompetent people, even after 3 primary doses.16-18 With a lower total antibody level, any waning of protection can leave people more susceptible to breakthrough infections. In severely immunocompromised people, this can result in severe disease and death.19,20 ATAGI therefore recommends the additional booster dose for these people (aged 16 years and older) based on first principles. However, ATAGI notes that there are no studies to date on the use of a 5th dose of vaccine in this population.

Aboriginal and Torres Strait Islander people aged 50 years and above are recommended for an additional booster dose. Data provided to ATAGI by the National Aboriginal and Torres Strait Islander Advisory Group on COVID-19 showed that, between 15 December 2021 and 13 March 2022 (Omicron wave), crude rates of hospitalisation and death in Aboriginal and Torres Strait Islander people aged 50 years and older were 2.5 to 5 times higher than in the non-Indigenous population. This was despite equivalent vaccine coverage in Indigenous and non-Indigenous people. For other respiratory infections such as influenza and invasive pneumococcal disease, younger Aboriginal and Torres Strait Islander people have comparable risks to older non-Indigenous Australians.21,22 Therefore, ATAGI recommends this additional booster dose for Aboriginal and Torres Strait Islander people from age 50 years.

Medical co-morbidities, when considered independently from age, have a smaller contribution to an increased risk of severe COVID-19 than age.13,23 Studies of risk factors have mainly been conducted in the pre-Omicron era, and later studies indicate that Omicron infection is less severe than infection with previous variants.24-27 ATAGI does not currently recommend an additional booster dose in people with co-morbidities aged under 65 years, but continues to monitor evidence of the risk of severe disease due to the Omicron variant in this group.

Most healthy or lower-risk adults who have received a 2-dose primary course and a single booster dose will have a low likelihood of severe illness from the Omicron variant and are currently not recommended for an additional booster dose.25,28

Booster doses and effects on transmission

Early pre-print data suggest that the benefit of first booster doses in preventing onward transmission in breakthrough cases of Omicron may be substantially less than Delta and may be short-lived.29,30 Data from Israel showed that the additional protection against infection of an additional booster dose may be modest (11–30% reduction compared with those who received only one booster).12 Up to 30% of second booster recipients who had breakthrough infection were asymptomatic and their virus levels were no different from people who received only one booster, suggesting that the additional booster dose may not significantly reduce onward virus transmission in infected people.12 Several studies have also suggested that in healthcare workers, COVID-19 infections are more likely to arise from community transmission than exposure in the workplace because of the routine use of appropriate infection control procedures and personal protective equipment in the workplace.31-33 In one study of 24,749 healthcare workers, no workplace factors were associated with seropositivity, but seropositivity was associated with community COVID-19 contact (adjusted odds ratio 3.5, 95% CI 2.9–4) and community COVID-19 cumulative incidence (OR 1.8, 95% CI 1.3–2.6).33

There is insufficient evidence at present to support vaccinating healthy workers in settings such as aged care, disability care and healthcare settings solely on the grounds of reducing transmission to others.

Key areas of uncertainty

ATAGI is continuing to closely monitor scientific data as it becomes available including in key areas of uncertainty.

Epidemiology

 The future epidemiology beyond the current rise in BA.2 infections is difficult to predict due to numerous complex factors, including increased immunity in people from past Omicron infection, waning vaccine-derived immunity, relaxation of mask-wearing, physical distancing and other public health measures, and seasonal factors including increased indoor gathering during winter months. ATAGI will continue to monitor changes in epidemiology and impacts on population groups and may update its advice on additional booster doses.

Future variants

The potential remains for new variants of concern to appear and spread rapidly. The timing of this is unpredictable. It is unlikely that a variant-specific vaccine could be developed, tested and produced in sufficient time to counter a new variant. The severity and transmissibility of future variants will not be known until they appear. Severity could range from relatively mild disease (as with Omicron) to severity similar to or greater than the Delta strain. ATAGI will monitor how well current vaccines work to protect again new variants of concern.

New formulations of vaccines

The timeline for availability of variant-based vaccines, their strain composition and evidence of their efficacy/effectiveness is unknown. The incremental benefit of Omicron-specific vaccines or formulations that target multiple variants will need to be studied against Omicron and future variants and compared with extra doses of current vaccines based on the ancestral strain. ATAGI will use this information to determine whether a switch to newer vaccines is warranted.

Potential for reduced efficacy with repeated booster doses at short intervals

Studies of other vaccines (e.g. meningococcal and pneumococcal polysaccharide vaccines) have shown that repeated administration of boosters within a short time frame may result in blunting of vaccine-induced antibody responses.34 A pre-print study of an inactivated SARS-CoV-2 vaccine (not available in Australia) suggests lower peak antibody levels after a second booster dose compared with the first booster, though whether this may apply to other vaccine platforms is unclear.35 ATAGI will monitor data on the kinetics of the antibody response to repeated COVID-19 vaccine doses to ensure that additional doses are not counterproductive to the immune response.

Safety of an additional booster dose

While local and systemic adverse events after a 4th dose appear short-lived and similar to previous doses,12 data are limited. ATAGI will continue to monitor safety data on more serious adverse events, including myocarditis, to guide whether additional boosters should be recommended in younger people.

Role of therapeutic treatments for COVID-19

ATAGI notes the expanding role and availability of effective intravenous and oral medical treatments (monoclonal antibodies and antivirals) that can reduce the risk of severe illness when given early in COVID-19 infection. ATAGI notes that such treatments could reduce the urgency or the need for a population-wide booster vaccination program to protect high-risk people, if these treatments are readily available, safe and effective. ATAGI continues to monitor the availability and efficacy of therapeutic agents used in the treatment of COVID-19 infection, including the emergence of resistance.

References

  1. World Health Organization. Statement on Omicron sublineage BA.2. 2022. Available from: https://www.who.int/news/item/22-02-2022-statement-on-omicron-sublineage-ba.2 (Accessed 15/3/2022).
  2. Wolter N, Jassat W, group D-Ga, von Gottberg A, Cohen C. Clinical severity of Omicron sub-lineage BA.2 compared to BA.1 in South Africa. medRxiv 2022:2022.02.17.22271030. Available from: https://www.medrxiv.org/content/medrxiv/early/2022/02/19/2022.02.17.22271030.full.pdf.
  3. UK Health Security Agency. COVID-19 vaccine surveillance report Week 10 - 10 March 2022. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1060030/vaccine-surveillance-report-week-10.pdf (Accessed 15/3/2022).
  4. Australian Government. Operation COVID Shield. COVID-19 Vaccine Roll-out - 14 March 2022. Available from: https://www.health.gov.au/resources/collections/covid-19-vaccination-daily-rollout-update (Accessed 9/3/2022).
  5. COVID-19 National Incident Room Surveillance Team. COVID-19 Australia: Epidemiology Report 56: Reporting period ending 5 December 2021. Commun Dis Intell (2018) 2021;45. Available from.
  6. The Australian Government Department of Health. Coronavirus (COVID-19) case numbers and statistics. 2022. Available from: https://www.health.gov.au/health-alerts/covid-19/case-numbers-and-statistics (Accessed 15/3/2022).
  7. Chemaitelly H, Ayoub HH, AlMukdad S, et al. Duration of protection of BNT162b2 and mRNA-1273 COVID-19 vaccines against symptomatic SARS-CoV-2 Omicron infection in Qatar. medRxiv 2022:2022.02.07.22270568. Available from: https://www.medrxiv.org/content/medrxiv/early/2022/02/08/2022.02.07.22270568.full.pdf.
  8. Ferdinands JM, Rao S, Dixon BE, et al. Waning 2-Dose and 3-Dose Effectiveness of mRNA Vaccines Against COVID-19-Associated Emergency Department and Urgent Care Encounters and Hospitalizations Among Adults During Periods of Delta and Omicron Variant Predominance - VISION Network, 10 States, August 2021-January 2022. MMWR Morb Mortal Wkly Rep 2022;71:255-63. Available from: https://www.ncbi.nlm.nih.gov/pubmed/35176007.
  9. UK Health Security Agency. COVID-19 vaccine surveillance report Week 8 - 24 February 2022. 2022. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1057125/Vaccine_surveillance_report_-_week-8.pdf (Accessed 27/02/2022).
  10. Tseng HF, Ackerson BK, Luo Y, et al. Effectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variants. Nat Med 2022. Available from: https://www.ncbi.nlm.nih.gov/pubmed/35189624.
  11. Bar-On YM, Goldberg Y, Mandel M, et al. Protection by 4th dose of BNT162b2 against Omicron in Israel. medRxiv 2022:2022.02.01.22270232. Available from: https://www.medrxiv.org/content/medrxiv/early/2022/02/01/2022.02.01.22270232.full.pdf.
  12. Regev-Yochay G, Gonen T, Gilboa M, et al. Efficacy of a Fourth Dose of Covid-19 mRNA Vaccine against Omicron. N Engl J Med 2022:2022.02.15.22270948. Available from: https://www.ncbi.nlm.nih.gov/pubmed/35297591
  13. Centers for Disease Control and Prevention. Underlying Medical Conditions Associated with Higher Risk for Severe COVID-19: Information for Healthcare Professionals. 2022. Available from: https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/underlyingconditions.html (Accessed 10/3/2022).
  14. andes SD, Turk MA, Ervin DA. COVID-19 case-fatality disparities among people with intellectual and developmental disabilities: Evidence from 12 US jurisdictions. Disability and Health Journal 2021;14. Available from: <Go to ISI>://WOS:000696982000023 https://www.sciencedirect.com/science/article/pii/S1936657421000625?via%3Dihub.
  15. Choi JW, Han EN, Lee SG, Shin J, Kim TH. Risk of COVID-19 and major adverse clinical outcomes among people with disabilities in South Korea. Disability and Health Journal 2021;14. Available from: <Go to ISI>://WOS:000696982000003 https://www.sciencedirect.com/science/article/pii/S193665742100073X?via%3Dihub.
  16. Parker EPK, Desai S, Marti M, et al. Response to additional COVID-19 vaccine doses in people who are immunocompromised: a rapid review. The Lancet Global Health 2022;10:e326-e8. Available from: https://doi.org/10.1016/S2214-109X(21)00593-3 (Accessed 2022/03/17).
  17. Galmiche S, Luong Nguyen LB, Tartour E, et al. Immunological and clinical efficacy of COVID-19 vaccines in immunocompromised populations: a systematic review. Clin Microbiol Infect 2022;28:163-77. Available from: https://www.ncbi.nlm.nih.gov/pubmed/35020589.
  18. Lee A, Wong SY, Chai LYA, et al. Efficacy of covid-19 vaccines in immunocompromised patients: systematic review and meta-analysis. BMJ 2022;376:e068632. Available from: https://www.ncbi.nlm.nih.gov/pubmed/35236664.
  19. Liu C, Lee J, Ta C, et al. A Retrospective Analysis of COVID-19 mRNA Vaccine Breakthrough Infections - Risk Factors and Vaccine Effectiveness. medRxiv 2021. Available from.
  20. Sun J, Zheng Q, Madhira V, et al. Association Between Immune Dysfunction and COVID-19 Breakthrough Infection After SARS-CoV-2 Vaccination in the US. JAMA Intern Med 2022;182:153-62. Available from: https://www.ncbi.nlm.nih.gov/pubmed/34962505 (Accessed 3/17/2022).
  21. National Centre for Immunisation Research and Surveillance, Ioannides S, Beard F, et al. Vaccine Preventable Diseases and Vaccination Coverage in Aboriginal and Torres Strait Islander People, Australia, 2011-2015. Commun Dis Intell (2018) 2019;43. Available from: https://www.ncbi.nlm.nih.gov/pubmed/31412692.
  22. Australian Government Department of Health. Australian Immunisation Handbook. 2021. Available from: https://immunisationhandbook.health.gov.au/ (Accessed 21/09/2021).
  23. Liu B, Spokes P, He W, Kaldor J. High risk groups for severe COVID-19 in a whole of population cohort in Australia. BMC Infectious Diseases 2021;21:685. Available from: https://doi.org/10.1186/s12879-021-06378-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282405/pdf/12879_2021_Article_6378.pdf.
  24. Lauring AS, Tenforde MW, Chappell JD, et al. Clinical Severity and mRNA Vaccine Effectiveness for Omicron, Delta, and Alpha SARS-CoV-2 Variants in the United States: A Prospective Observational Study. medRxiv 2022:2022.02.06.22270558. Available from: https://www.medrxiv.org/content/medrxiv/early/2022/02/07/2022.02.06.22270558.full.pdf.
  25. Nyberg T, Ferguson NM, Nash SG, et al. Comparative Analysis of the Risks of Hospitalisation and Death Associated with SARS-CoV-2 Omicron (B.1.1.529) and Delta (B.1.617.2) Variants in England. SSRN Electronic Journal 2022. Available from: https://ssrn.com/abstract=4025932.
  26. Sheikh A, Kerr S, Woolhouse M, McMenamin J, Robertson C. Severity of Omicron variant of concern and vaccine effectiveness against symptomatic disease: national cohort with nested test negative design study in Scotland. 2021. Available from: https://www.pure.ed.ac.uk/ws/portalfiles/portal/245818096/Severity_of_Omicron_variant_of_concern_and_vaccine_effectiveness_against_symptomatic_disease.pdf (Accessed 18/01/2021).
  27. Ulloa AC, Buchan SA, Daneman N, Brown KA. Estimates of SARS-CoV-2 Omicron Variant Severity in Ontario, Canada. JAMA 2022. Available from: https://www.ncbi.nlm.nih.gov/pubmed/35175280 (Accessed 3/17/2022).
  28. Hippisley-Cox J, Coupland CA, Mehta N, et al. Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study. BMJ 2021;374:n2244. Available from: https://www.ncbi.nlm.nih.gov/pubmed/34535466.
  29. Allen H, Tessier E, Turner C, et al. Comparative transmission of SARS-CoV-2 Omicron (B.1.1.529) and Delta (B.1.617.2) variants and the impact of vaccination: national cohort study, England. medRxiv 2022:2022.02.15.22271001. Available from: https://www.medrxiv.org/content/medrxiv/early/2022/02/17/2022.02.15.22271001.full.pdf.
  30. Jalali N, Brustad HK, Frigessi A, et al. Increased household transmission and immune escape of the SARS-CoV-2 Omicron variant compared to the Delta variant: evidence from Norwegian contact tracing and vaccination data. medRxiv 2022:2022.02.07.22270437. Available from: https://www.medrxiv.org/content/medrxiv/early/2022/02/08/2022.02.07.22270437.1.full.pdf https://www.medrxiv.org/content/medrxiv/early/2022/02/18/2022.02.07.22270437.full.pdf.
  31. Ganz-Lord FA, Segal KR, Gendlina I, Rinke ML, Weston G. SARS-CoV-2 exposures among healthcare workers in New York City. Occupational Medicine-Oxford. Available from: <Go to ISI>://WOS:000764826600001.
  32. Gohil SK, Quan KA, Madey KM, et al. Infection prevention strategies are highly protective in COVID-19 units while main risks to healthcare professionals come from coworkers and the community. Antimicrob Resist Infect Control 2021;10:163. Available from: https://www.ncbi.nlm.nih.gov/pubmed/34809702.
  33. Jacob JT, Baker JM, Fridkin SK, et al. Risk Factors Associated With SARS-CoV-2 Seropositivity Among US Health Care Personnel. JAMA Netw Open 2021;4:e211283. Available from: https://www.ncbi.nlm.nih.gov/pubmed/33688967 https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2777317/jacob_2021_oi_210063_1614704384.72276.pdf (Accessed 3/20/2022).
  34. Poolman J, Borrow R. Hyporesponsiveness and its clinical implications after vaccination with polysaccharide or glycoconjugate vaccines. Expert Rev Vaccines 2011;10:307-22. Available from.
  35. Wang J, Deng C, Liu M, et al. Four doses of the inactivated SARS-CoV-2 vaccine redistribute humoral immune responses away from the Receptor Binding Domain. medRxiv 2022:2022.02.19.22271215. Available from: https://www.medrxiv.org/content/medrxiv/early/2022/02/21/2022.02.19.22271215.full.pdf.

Help us improve health.gov.au

If you would like a response please use the enquiries form instead.