Information for health professionals on syphilis

This fact sheet provides information for health professionals about the sexually transmissible infection (STI) syphilis.


Information for health professionals on syphilis

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Fact sheet
General public

Syphilis is an STI that can cause short and long-term health issues if left untreated.

This fact sheet provides information about:

  • syphilis and its symptoms, including primary, secondary, latent, tertiary and congenital syphilis
  • the infectious syphilis outbreak currently happening across Australia
  • when to test for syphilis.

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Information for health professional on syphilis 

Syphilis is on the rise in Australia among men who have sex with men, women of childbearing age and Aboriginal and Torres Strait Islander peoples living in outbreak areas. You may see patients presenting at your clinic who require testing and treatment.

Key information about syphilis and symptomology 

Syphilis is a sexually transmissible infection (STI) caused by the bacterium Treponema pallidum. It is a serious disease that can cause short and long-term health issues if left untreated. With early diagnosis, most people can receive treatment and recover from syphilis. Clinical presentation may be highly variable and many cases do not follow the classical stages listed below. Syphilis can be asymptomatic. Symptoms vary depending on the stage of infection.

Primary syphilis 

The primary lesion, a chancre, begins as a papule 10 to 90 days after infection. It ulcerates to form a relatively painless lesion at the site of infection (e.g. lip, tongue, pharynx, anus, rectum) and may be accompanied by regional lymphadenopathy. However, atypical multiple and painful lesions can occur. The ulcer usually heals spontaneously over the course of a few weeks. 

Secondary syphilis 

Secondary syphilis usually occurs 4 to 10 weeks after the onset of the primary lesion. Symptoms include headache, fatigue, lymphadenopathy, low grade fever, sore throat, rash, mucocutaneous lesions and alopecia. Ocular and neurological symptoms may also occur. Untreated secondary syphilis symptoms persist for 3 to 12 weeks, after which an untreated patient enters the early latent phase. An untreated patient can remain infectious for up to two years until the disease progresses to the late latent stage. 

Latent syphilis 

Syphilis of more than two years duration, in the absence of clinical signs or history of treatment, is called late latent syphilis. People with late latent syphilis can be asymptomatic for many years. The patient is still infected with syphilis, however the infection remains latent or progresses to tertiary syphilis.

Tertiary syphilis 

About one-third of people with untreated syphilis develop tertiary syphilis. This is a grave condition which can cause brain infections, dementia, lung and heart failure, blindness and death if left untreated.

Congenital syphilis 

Vertical transmission can occur anytime during pregnancy and at any stage of syphilis. Untreated syphilis during pregnancy can lead to miscarriage, stillbirth, premature births, low birth weight and death of the baby shortly after birth. A baby with congenital syphilis can experience serious health issues that affect their growth and development, such as permanent organ and brain damage. Some babies won’t show symptoms until they’re older, which can lead to a delay in diagnosis.

Infectious syphilis outbreak

In 2020, notifications of infectious syphilis in Australia increased by nearly 90 per cent from recorded rates in 2015. There is an ongoing outbreak of infectious syphilis affecting young Aboriginal and Torres Strait Islander peoples, mainly aged between 15 and 34 years. For more information on the outbreak regions, go to and search “syphilis outbreak”. There is also an increase in infectious syphilis among non-Indigenous and Aboriginal and Torres Strait Islander women outside of outbreak declared regions, including in major cities. Between 2015 and 2020, rates of infectious syphilis in women aged 15 to 44 increased by 233 per cent.


It is important that you regularly screen your patients for syphilis once they become sexually active. Regular and comprehensive STI testing should be offered to patients belonging to priority populations, including men who have sex with men, women of childbearing age, and those residing in outbreak regions, including Aboriginal and Torres Strait Islander communities. If your patient is pregnant, it is recommended that they be tested at their first antenatal visit or during the first 12 weeks of their pregnancy to prevent congenital syphilis. If they live in areas impacted by the ongoing syphilis outbreak, they should be tested at the following intervals:

  • the first antenatal visit
  • 28 and 36 weeks
  • the time of birth
  • 6 weeks after the birth.

Don't fool around with syphilis. Further information: 

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