Principles set out in this document are intended to apply to tests used for the detection, characterisation and quantification of nucleic acids. In medical laboratories, there are two main applications of these techniques:

    • testing for human genetic conditions (inherited disorders and acquired somatic cell disorders)
    • testing for microorganisms that can or may cause disease in humans. This document has two major sections:
    • Section 1 describes NPAAC standards and guidelines for nucleic acid detection and analysis in human genetics.
    • Section 2 describes NPAAC standards and guidelines for nucleic acid detection and analysis in medical microbiology.

    Laboratories that perform nucleic acid amplification testing in human genetics and medical microbiology must ensure that they comply with the standards set out in both sections of this document.