Key points:

  • Symptoms of depression and associated suicidal ideation may complicate cocaine withdrawal.
    Strength of evidence: 1 star

  • Dependence on other substances, particularly alcohol, is common among cocaine dependent persons.
    Strength of evidence: 1 star

  • Symptoms of severe depression and psychosis may complicate amphetamine withdrawal.
    Strength of evidence: 1 star

  • Detoxification from psychostimulants can usually be undertaken in a community setting with appropriate support and individualised management plans in place.
    Strength of evidence: 1 star

  • No pharmacotherapies have been empirically found to be effective for the treatment of psychostimulant withdrawal.
    Strength of evidence: 3 stars

  • Specific pharmacotherapies (e.g. antidepressants, benzodiazepines and antipsychotics) may be effective for concurrent management of specific comorbid symptoms.
    Strength of evidence: 2 stars