Australian national notifiable diseases case definitions
Creutzfeldt-Jakob disease (CJD) case definition - V1.0
This document contains the case definitions for Creutzfeldt-Jakob disease which is nationally notifiable within Australia. This definition should be used to determine whether a case should be notified.
Communicable Diseases Surveillance
Printable PDF version of Creutztfeldt-Jakob disease surveillance case definition (PDF 18 KB)
Version |
Status |
Last reviewed |
Endorsement date |
Implementation date |
|---|---|---|---|---|
| 1.0 | Initial CDNA case definition | CDWG November 2009 | CDNA 16 December 2009 | 1 July 2010 |
Reporting
Confirmed and probable cases should be notified. This includes sporadic, accidental and familial cases. (NB: a “confirmed” case is equivalent to the ANCJDR classification of “definite”)Confirmed case
A confirmed case requires laboratory definitive evidenceLaboratory definitive evidence
Neuropathological confirmation of CJD supplemented by immunochemical detection of protease-resistant PrP by western blot OR immunocytochemistry.Probable case
A probable case requires clinical evidence AND either electroencephalogram (EEG) or laboratory suggestive evidence.Laboratory suggestive evidence
Positive 14-3-3 protein CSF test.Clinical evidence
1. Progressive dementia of less than two years duration; AND2. At least 2 of the following clinical features:
- myoclonus
- visual or cerebellar signs
- pyramidal/extrapyramidal signs
- akinetic mutism.
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